His directorial debut, 'The Quispe Girls' (2013), produced by the Chilean company Fábula, achieved significant recognition by screening at the Venice Critics' Week and winning Best Cinematography. Sepúlveda has built an impressive reputation as an editor, particularly through his long-standing collaboration with acclaimed director Pablo Larraín. His editing work on 'The Club' (2015) earned the Silver Bear at the Berlinale, while his contribution to 'Jackie' (2016) resulted in a Spirit Awards nomination in 2017. The Sepúlveda-Larraín partnership continued with 'Ema' and 'Spencer,' the latter receiving an Academy Award nomination. Most recently, Sepúlveda completed the editing of the folk tale 'Queen of Bones,' produced by Appian Way, further demonstrating his versatility and excellence across both directing and editing disciplines in contemporary Chilean and international cinema.